• AKRIVIS HEALTH CARE
    "GOING BEYOND STEM CELLS FOR CELL FREE THERAPIES"

About

AKRIVIS HEALTH CARE PRIVATE LIMITED.

An ISO 9001 : 2015 Certified Company

We at Akrivis believe that health is directly related to quality of life and we strive in every manner possible in bringing health and well being to everyone who is associated with.

AKRIVIS HEALTH CARE PRIVATE LIMITED (AHCPL), was founded on the grounds of compassion and love of the very noble profession of caring for the fellow being which we now call it as healthcare.

For all that we are and we will ever be the key role is empowering the excellence of every human we will be associated with; we just happen to be in health care so... we are here to empower the keel of any health care instituion -the doctor!!!

Our Science

Mesenchymal Stem Cells (MSC):

“Unlocking Regenerative Potential, Harnessing the healing power of mesenchymal stem cell exosomes begins with isolating young, healthy mesenchymal stem cells (MSCs).

MSCs and other progenitor cells reside in many different types of tissue and accordingly exhibit tissue specific behavior. For example, neural stem cells may produce exosomes that have a favorable profile for regenerating damaged neural tissue, and cancer stem cells produce exosomes that promote the development of tumors. Placenta supports controlled development of fetal tissues, while modulating the natural immune and inflammatory response while suppressing malignant degeneration. This is where comes the magical properties of stem cells that owe scientific exploration for healthcare solutions. Like every other cell, MSC produce exosomes that have the potential of regeneration to introduce new revolution of cell free therapies in regenerative medicine."

For all that we are and we will ever be the key role is empowering the excellence of every human we will be associated with; we just happen to be in health care so... we are here to empower the keel of any health care instituion -the doctor!!!

Exosomes:

“Exosomes also called as Extracellular Vesicles (EV) are 30nm-150nm vesicles released by cells to direct cell to cell communication. The intrinsic, biological properties of MSC derived exosomes indicate their potential as active biologic agents for the treatment of injury and disease. Akrivis is investigating potential clinical applications of MSC derived exosomes as demonstrated in Diabetic wound healing based preclinical studies. Other projects in pipeline include Exosome biologics for COVID-19, Spinal Cord injury management, and very soon to launch Engineered exosomes.

Exosome revolution would indicate novel treatments and cures for many autoimmune, inflammatory, degenerative, traumatic and malignant conditions by optimizing the activity of cells and tissues involved in pathogenesis of disease and injury.”

Our Specialities

Anti-Apoptotic

MSC exosomes exogenously maintain cell viability and prevent apoptosis. Exosomes containing anti-apoptotic cargo help to slow, stop, or reverse tissue degeneration.

Immunomodulatory

MSC Exosomes are known to polarize immune cells to less inflammatory and more regulatory phenotypes. Therefore, incur immunomodulatory functions to mitigate conditions characterized by excessive immune response (for example, cytokine storm of COVID-19).

Pro-Angiogenic

MSC exosomes improve angiogenesis by stimulating endothelial cell function. Conditioning the blood supply to injured/diseased tissue helps to increase the survival of damaged cells and prevent tissue degeneration and impaired function.

Anti-Fibrotic

In preclinical studies, MSC exosomes optimize tissue remodeling in damaged skin and other tissues with improved type 1/Ill collagen ratio and normal organization of collagen fibers. Reducing fibrosis during wound healing or after tissue injury could improve scar formation and tissues.

Anti-Oxidant

Exosomal cargo proteins such as peroxiredoxins reduce the oxidation state of cells under oxidative stress, which is present in many disease states to effect tissue degeneration associated with aging.

Pro-Synthetic

MSC exosomes can activate fibroblasts to enhance extracellular matrix production in order to restore damaged tissues. Specific microRNA present in exosomes help to regenerate normal collagen in the skin or stimulate production of normal articular cartilage.

Post-transcriptional Regulation:

Exosomes induce post-transcriptional regulation due to the micro RNAs present in their cargo. Micro RNAs are generally involved in translational repression by cleaving mRNAs by specific mechanism.